The high-dose group had a higher rate of serum 25(OH)D restoration to optimal level than the low-dose group (82.8% vs 52.5%, respectively p < 0.001).

The remaining 119 patients (58 and 61 in the high- and low-dose groups, respectively) were included in the final analysis. Of the 140 patients who were enrolled, 21 patients were lost to follow-up during the study period. The number of patients who achieved optimal vitamin D level (serum 25(OH)D > 30 ng/mL), the proportion of patients who developed hypercalcemia, and the functional outcome were compared between groups. MethodsĪ total of 140 patients diagnosed with fragility hip fracture were randomly allocated to either the high-dose (60,000 IU/week) or low-dose (20,000 IU/week) vitamin D2 supplementation group for 12 weeks. The aim of this study was to evaluate the effectiveness and safety of vitamin D supplementation in fragility hip fracture patients compared between high- and low-dose vitamin D supplementation. Without the baseline serum 25(OH)D level, the appropriate dose of vitamin D supplementation is not known. However, measurement of 25-hydroxyvitamin D (25(OH)D) level is costly and may not be available in some centers.

Hypovitaminosis D can be observed in most fragility hip fracture patients.

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